首页|CHEMICAL CONSTITUENTS OF THE ENDOPHYTIC FUNGUS Bipolaris maydis DERIVЕВ FROM THE Kandelia candel
CHEMICAL CONSTITUENTS OF THE ENDOPHYTIC FUNGUS Bipolaris maydis DERIVЕВ FROM THE Kandelia candel
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Endophytic fungi derived from higher plants produce various bioactive metabolites [1].Such compounds have novel scaffolds and display interesting biological and pharmaceutical properties [2].The genus Bipolaris is associated with a number of plant pathogens [3].Recently,many cultures of Bipolaris fungi,i.e.,B.oryzae,B.eleusines,and B.sorokiniana,have been chemically studied [4-7].Dozens of compounds were reported,including diterpenes,sesterterpenes,and triterpenes.Most of the compounds possess unique chemical skeletons and display strong cytotoxicity toward cancer cell lines antifungal,enzyme inhibitory,and antilipid peroxidation activities.Bipolaris maydis was isolated from the mangrove plant Kandelia candel,popularly distributed in the South of Vietnam.Little is known on the chemistry of this fungus.In this paper,the isolation of seven compounds isolated from cultures of the titled fungus is described.Chemical structures of compounds were determined using NMR and MS spectroscopy as well as comparison with the data described in the literature.Seven compounds were elucidated as(R)-3-ethyl-6,7-dihydroxyphthalide(1),4-hydroxybenzoic acid(2),ergosta-4,6,8(14),22-tetraen-3-one(3),ergosterol peroxide(4),cerevi sterol(5),ergosterol(6),and emodin(7).To the best of our knowledge,all isolates(1-7)were isolated from this species for the first time.Compound 1 shared the same planar structure with(5)-3-ethyl-6,7-dihydroxyphthalide [8] but had positive specific rotation with [α]_D~(20)+110°(c 0.1,chloroform).Thus,this compound was elucidated to be a new compound whose absolute configuration was defined as(3R),Compound 1 showed moderate a-glucosidase inhibitory activity with IC_(50)77.9 ± 0.82)LiM(acarbose,positive control 83.7 ± 1.59 μM).
Thi-Minh-Dinh Tran、Thanh-Nha Tran、Thuc-Huy Duong
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Department of Biology,Ho Chi Minh City University of Education,Ho Chi Minh City,Vietnam
Department of Chemistry,Ho Chi Minh City University of Education,Ho Chi Minh City,Vietnam
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