Nuciferine is an aporphine alkaloid first isolated from Nelumbo nucifera Gaertn as the main bioactive ingredient. Additionally, it was also obtained from some other plants. Nuciferine exhibited diverse bioactivities such as antihyperlipidemic, anti-obesity, anti-fatty liver, antidiabetic, anti-hyperuricemic, antitumor, anti-inflammatory, antiviral, antioxidant activity, and thus has tremendous potential to be developed into drugs. This overview comprehensively summarized the widespread knowledge regarding to the chemistry and biology of nuciferine including isolation techniques, total synthesis, structural modification and structure-activity relationships, bioactivities, metabolism in vivo, and biosynthesis. Furthermore, an expectation was prospectively made for the future research on nuciferine through a careful analysis of the related literature up to early February 2022 and on the strength of our expertise in chemistry and biology of natural products.
NuciferineNelumbo nucifera GaertnSynthesisAnti-hyperlipidemia and anti-obesityMetabolismLOTUS NELUMBO-NUCIFERALIQUID-CHROMATOGRAPHYAPORPHINE ALKALOIDSTISSUE DISTRIBUTIONIN-VITROLEAVESIDENTIFICATIONMETABOLISMEXTRACTIONGAERTN
NSTL
Elsevier
