首页|Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia? A hypothesis in the era of COVID-19

Can chloroquine/hydroxychloroquine prove efficient in cancer cachexia? A hypothesis in the era of COVID-19

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  • NSTL
  • Elsevier
Cancer cachexia (CC) is a progressive loss of muscle mass (with or without a decrease of adipose tissue)。 Gradual deterioration of the patient's fitness is resistant to nutritional intervention。 The biochemical foundation of observed catabolism， detrimental protein， and energy balance is complex。 However， the generalized inflammatory response plays a vital role。 It is a kind of cytokine storm， which involves increased activity of TNF-alpha， IL-1， IL-6， and INF-gamma。 Pharmacological treatment of cachexia consists mainly of progestagens and glucocorticosteroids。 Still， the assessment of new options limiting the harmful impact of cachexia could be beneficial。 Chloroquine (CQ) and hydroxychloroquine (HCQ) are old antimalarial agents endowed with immunomodulatory properties。 Being potent autophagy inhibitors， they could lead to a form of intracellular starvation in both cytokine-releasing cells and cancer cells， thus limiting the harmful impact of CC。 CQ and HCQ are also efficient in particular connective tissue disorders。 They have gained special attention since the World Health Organization announced the coronavirus disease 2019 (COVID-19) pandemic。 According to initial reports， people with a severe inflammatory reaction showed significant benefits。 Possibly they could not be attributed to the antiviral activity alone。 It is worth noting that the cytokine storm in COVID-19， connective tissue disorders， and cancer cachexia share some similarities。 Therefore， we hypothesize that low doses of CQ/HCQ may prove efficient in cancer cachexia。

CachexiaCancerChloroquineHydroxychloroquineCytokine stormAutophagy

Kiedrowski, Miroslaw、Kapala, Przemyslaw、Kiedrowska, Marlena、Skoczynska, Anna、Czerw, Aleksandra、Deptala, Andrzej

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Ewdomed Ewa Szulecka Fdn & Home Hosp, Al Wojska Polskiego 6, PL-05520 Konstancin Jeziorna, Poland

Natl Med Inst, Dept Epidemiol & Clin Microbiol, Chelmska 30-34, PL-00725 Warsaw, Poland

Med Univ Warsaw, Fac Hlth Sci, Dept Hlth Econ & Med Law, Ul Zwirki & Wigury 61, PL-02091 Warsaw

Minist Anterior & Adm Warsaw, Cent Clin Hosp, Clin Dept Oncol & Hematol, Ul Woloska 137, PL-02507

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2021

10.1016/j.mehy.2020.110434

Medical hypotheses

Medical hypotheses

SCI
ISSN：0306-9877
年,卷(期)：2021.146
  • 41