首页|Activity control of pH-responsive photosensitizer bis(6-quinolinoxy)P(V) tetrakis(4-chlorophenyl)porphyrin through intramolecular electron transfer
Activity control of pH-responsive photosensitizer bis(6-quinolinoxy)P(V) tetrakis(4-chlorophenyl)porphyrin through intramolecular electron transfer
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NSTL
Elsevier
Strong photooxidative activity of dichloroP(V)tetrakis(4-chlorophenyl)porphyrin via electron transfer was expected. To control the activity of this P(V)porphyrin, bis(6-quinolinoxy)P(V)tetrakis(4-chlorophenyl)porphyrin (QuinP(V)TClPP), was synthesized. The pK(a) of a protonated quinoline moiety, the electron donor, was estimated to be 4.6. The singlet excited state of QuinP(V)TClPP was quenched via intramolecular electron transfer under neutral condition. Under an acidic condition, the fluorescence intensity and the singlet oxygen (O-1(2)) generation yield by photoexcited QuinP(V)TClPP were significantly increased through protonation of the quinoline moiety. The photosensitized damage of human serum albumin by QuinP(V)TClPP through O-1(2) generation and electron transfer mechanisms was effectively enhanced under an acidic condition.
NSTL
Elsevier
