Tetrahedron letters2022，Vol.996.DOI:10.1016/j.tetlet.2022.153840

Base-catalyzed cascade [3+2] spiroannulation/aromatization of in situ generated tosyldiazomethane (TsDAM) with (Z)-aurones: An efficient access to polysubstituted pyrazole derivatives

Huang, Jie Sun, Shaofa Ma, Ping Yom, Clairissa Xing, Yalan Wu, Yang Wang, Gangqiang
Tetrahedron letters2022，Vol.996.DOI:10.1016/j.tetlet.2022.153840
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  • NSTL
  • Elsevier

Base-catalyzed cascade [3+2] spiroannulation/aromatization of in situ generated tosyldiazomethane (TsDAM) with (Z)-aurones: An efficient access to polysubstituted pyrazole derivatives

Huang, Jie 1Sun, Shaofa 1Ma, Ping 1Yom, Clairissa 2Xing, Yalan 2Wu, Yang 1Wang, Gangqiang1
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作者信息

  • 1. Hubei Univ Sci & Technol
  • 2. William Paterson Univ New Jersey
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Abstract

An efficient metal-free approach to access in situ generated tosyldiazomethane (TsDAM) and (Z)-aurones containing pyrazoles under mild conditions has been developed. This methodology involves 1,3-dipolar cycloaddition in an aqueous system, followed by an aromatization with a CAO bond cleavage in an acidic separation environment. We observed good yields under mild conditions, along with synthetic versatility and high functional group compatibility. (c) 2022 Elsevier Ltd. All rights reserved.

Key words

Cascade Cyclization/(Z)-aurones/tosyldiazomethane (TsDAM)/Pyrazoles/BESTMANN-OHIRA REAGENT/FREE DOMINO REACTION/ONE-POT SYNTHESIS/1/3-DIPOLAR CYCLOADDITION/REGIOSELECTIVE SYNTHESIS/FACILE/SCAFFOLDS/AURONES/ESTERS

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量1
参考文献量49
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