Abstract
An efficient and catalyst free protocol has been disclosed for aza-Michael addition reaction of pyrazoles with 2-aryl-3-nitro-2H-chromene derivatives, which provides synthetically important 4-pyrazole-3nitrobenzopyrans at room temperature. In this one-pot transformation, good to excellent yield of the products up to 84% were obtained and generated a new C-N bond. The relative configuration of the product was characterized by a single crystal X-ray crystallography. This protocol is extensively applicable for the wide substrate scope, high yields, easy accessibility, as well as base and catalyst free condition. (c) 2022 Elsevier Ltd. All rights reserved.
NSTL
Elsevier