首页|Comparative analysis of iTRAQ-based proteome profiles of Schistosoma japonicum female worms coming from single-sex infections and bisexual for infections
Comparative analysis of iTRAQ-based proteome profiles of Schistosoma japonicum female worms coming from single-sex infections and bisexual for infections
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NSTL
Elsevier
In schistosomiasis, eggs produced by bisexual infected mature female schistosome worms (FMS) are the main cause of pathological damage to the host and the dissemination of the disease. Single-sex infected female worms (FSS) cannot completely develop to sexual maturity or produce normal eggs. In this study, isobaric tags for relative and absolute quantitation (iTRAQ)-coupled LC-MS/MS was used to explore the proteome of FSS and FMS of Schistosoma japonicwn. A total of 1477 differentially expressed proteins (fold change > 1.2, P < .05) between FSS and FMS were identified. Bioinformatics analysis indicated that FMS expressed more proteins related to biosynthetic processes, such as eggshell synthesis, ribosomal synthesis, protein folding, cellular detoxification, and metabolic processes such as protein metabolism and glucose metabolism, whereas more proteins related to locomotion and oxidative phosphorylation were expressed in FSS. Our identification and analysis of differentially expressed proteins between FMS and FSS provides new insights to elucidate the molecular biological mechanisms of female worm sexual maturation and reproduction.
NSTL
Elsevier
