首页|Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications
Zinc substituted hydroxyapatite/silk fiber/methylcellulose nanocomposite for bone tissue engineering applications
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NSTL
Elsevier
? 2022 Elsevier B。V。Fibrous bio-composite based on silk fiber (SF)， methylcellulose (MC) and zinc substituted hydroxyapatite (ZnxCa5-x (PO4)3(OH) (x = 0。1， 0。2， 0。5 and 1。0)) were obtained with the use of electrospinning (E-Spin) method。 XRD， FTIR， SEM-EDAX， swelling， porosity and mechanical properties of the composites were analyzed。 The elongation at break (%) (20。97–317。20 %) and tensile strength (29。85–110。92 MPa) of nanocomposites was increased with an increase in the wt% of Zn-HAP in SF/MC。 An increase in the zone of inhibition with an increase in the wt% of Zn-HAP into the SF/MC was observed against E。 coli (34 ± 0。33 to 47 ± 1。15)， S。 aureus (28 ± 0。24 to 38 ± 1。32) and C。 albicans (24 ± 0。36 to 39 ± 2。36)。 The in-vitro biomineralization study using SBF (simulated body fluid) showed apatite layer formation on the nano-composite。 In addition， the optimized (20 wt % of Zn1。0Ca4。0(PO4)3(OH)/SF/MC) nano-composite showed good cell viability against human bone osteosarcoma (MG-63) cells。
NSTL
Elsevier
