Tetrahedron letters2022,Vol.904.DOI:10.1016/j.tetlet.2021.153615

Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction

Yuan G.-Q. Chen W.-J.
Tetrahedron letters2022,Vol.904.DOI:10.1016/j.tetlet.2021.153615

Electrochemical synthesis of 1,2,3-trisubstituted pyrroles from β-dicarbonyl compounds, aldehydes and amines via radical addition reaction

Yuan G.-Q. 1Chen W.-J.1
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作者信息

  • 1. Key Laboratory of Functional Molecular Engineering of Guangdong Province School of Chemistry and Chemical Engineering South China University of Technology
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Abstract

? 2021 Elsevier LtdAn efficient electrochemical synthesis of 1,2,3-trisubstituted pyrroles was developed by one-pot three-component reaction of β-dicarbonyl compounds, aldehydes with amines. The target products could be obtained in good to excellent yields. Our investigations indicate that β-enamino ketone is a key intermediate in this transformation and the reaction mechanism may involve a radical addition reaction pathway.

Key words

Electrosynthesis/Iodine-mediated/Pyrroles/Radical reaction/Three-component reaction/VXAMXCWXLVQIGC-UHFFFAOYSA-N

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN:0040-4039
参考文献量25
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