首页|The effect of Iodixanol on the thermodynamic properties of blood components
The effect of Iodixanol on the thermodynamic properties of blood components
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NSTL
Elsevier
The effects of Iodixanol contrast medium were studied on human blood samples with differential scanning calorimetry (DSC). Measurements on anticoagulated and non-anticoagulated samples revealed that the components of the plasma and serum turned into a thermodynamically less stable state in the presence of Iodixanol. The thermal parameters of the main transition peak changed in the same way for both the plasma and serum erythrocyte samples in the presence of Iodixanol. The T-max1 values of the main thermal transition were not dramatically different (similar to 70 degrees C). The T-max2 value of the peak at higher temperature range (similar to 80-85 degrees C) shifted considerably (by 3.97-4.89 degrees C) towards the lower temperature range, while the Delta H value showed a significant drop (similar to 61%) in the presence of higher concentration of Iodixanol. The results suggest that Iodixanol in blood samples can induce specific changes in the structure of blood components by altering the fundamental thermodynamic properties of the underlying biological system.
Human bloodSerumPlasmaContrast agentIodixanolCalorimetryDIFFERENTIAL SCANNING CALORIMETRYIODINATED CONTRAST-MEDIADSC ANALYSISSTRUCTURAL TRANSITIONSMULTICENTERPLASMASAFETY
NSTL
Elsevier
