首页|Targeting Oxidative Stress and Inflammatory Response for Blood–Brain Barrier Protection in Intracerebral Hemorrhage

Targeting Oxidative Stress and Inflammatory Response for Blood–Brain Barrier Protection in Intracerebral Hemorrhage

扫码查看
原文链接
  • NSTL
  • Mary Ann Liebert, Inc
Significance: Blood–brain barrier (BBB) disruption is a major pathological change after intracerebral hemorrhage (ICH) and is both the cause and result of oxidative stress and of the immune response post-ICH. These processes contribute to ICH-induced brain injury.Recent Advances: After the breakdown of cerebral vessels, blood components, including erythrocytes and their metabolites, thrombin, and fibrinogen, can access the cerebral parenchyma through the compromised BBB, triggering oxidative stress and inflammatory cascades. These aggravate BBB disruption and contribute to further infiltration of blood components, resulting in a vicious cycle that exacerbates brain edema and neurological injury after ICH. Experimental and clinical studies have highlighted the role of BBB disruption in ICH-induced brain injury.Critical Issues: In this review, we focus on the strategies to protect the BBB in ICH. Specifically, we summarize the evidence and the underlying mechanisms, including the ICH-induced process of oxidative stress and inflammatory response, and we highlight the potential therapeutic targets to protect BBB integrity after ICH.Future Directions: Future studies should probe the mechanism of ferroptosis as well as oxidative stress-inflammation coupling in BBB disruption after ICH and investigate the effects of antioxidants and immunomodulatory agents in more ICH clinical trials. Antioxid. Redox Signal. 37, 115–134.

blood–brain barrierblood componentsinflammatory responseintracerebral hemorrhageoxidative stress

Shengpan Chen、Lingzhi Li、Chao Peng、Chunjing Bian、Pinar Eser Ocak、John H. Zhang、Yong Yang、Dong Zhou、Guangzhong Chen、Yumin Luo

展开 >

Department of Neurosurgery, Guangdong Provincial People's Hospital, Guangdong Institute of

Institute of Cerebrovascular Disease Research and Department of Neurology, Xuanwu Hospital of

Department of General Surgery, Xuanwu Hospital, Capital Medical University

Department of Neurosurgery, Uludag University School of Medicine

Department of Physiology and Pharmacology, School of Medicine, Loma Linda University

展开 >

2022

10.1089/ars.2021.0072

Antioxidants and redox signalling

Antioxidants and redox signalling

ISSN：1523-0864
年,卷(期)：2022.37(1/3)
  • 21
  • 166