首页|Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels
Ophthalmic delivery of hydrophilic drugs through drug-loaded oleogels
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NSTL
Elsevier
Purpose: Delivering ophthalmic drugs to the target tissues in eye is challenging due to transport barriers. Rapid tear clearance of the drug instilled as eye drops to treat anterior segment diseases results in a low ocular permeability of 1-5%. The blood-retina barrier and clearance mechanisms which eliminate drug from tears and ocular tissue make systemic or topical delivery techniques ineffective in delivering drugs to the back of the eye. Intravitreal injections into the eye are the only viable option even though repeated monthly injections increase risk for infections and retinal detachment. Controlled and sustained drug delivery could reduce the frequency of injections and lower the associated risk of side effects.
Macoon, Russell、Chauhan, Anuj
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Univ Florida, Dept Chem Engn, Gainesville, FL 32611 USA
Colorado Sch Mines, Dept Chem Engn, Golden, CO 80401 USA
NSTL
Elsevier
