首页|Altered amyloid-beta and tau proteins in neural-derived plasma exosomes in obstructive sleep apnea
Altered amyloid-beta and tau proteins in neural-derived plasma exosomes in obstructive sleep apnea
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NSTL
Elsevier
Objective: The purpose of our study was to investigate the correlation between neural-derived plasma exosomal amyloid-beta (A beta)42, total tau (T-tau) and tau phosphorylated at threonine 181 (P-T181-tau) protein levels and cognitive impairment in patients with obstructive sleep apnea (OSA). Methods: There were 122 subjects without dementia included in the study: 27 patients with OSA and mild cognitive impairment (MCI), 52 OSA patients without MCI, and 43 subjects diagnosed with simple snoring but not MCI as the control group. Neuronal-derived exosomal proteins were measured by ELISA kits for A beta 42, T-tau and P-T181-tau. The cognitive function was evaluated by a Chinese version of the Montreal Cognitive Assessment (MoCA) questionnaire, and a normal cognitive score was >= 26. Results: The exosomal A beta 42, T-tau and P-T181-tau levels in the OSA with MCI group were higher than those in the OSA group. The A beta 42, T-tau, and P-T181-tau levels in the plasma neuronal-derived exosomes were associated with an increased risk of cognitive impairment in OSA patients after additional adjustment for age, gender, education, vascular risk factors, apnea-hypopnea index (AHI) or oxygen reduction index (ODI). Furthermore, there were also significant associations between A beta 42, T-tau, and PT181-tau in neural-derived plasma exosomes and Epworth Sleepiness Scale, AHI, and ODI in OSA patients. After 1 year of continuous positive airway pressure (CPAP) intervention, the neuronal-derived exosome levels of A beta 42, T-tau, and P-T181-tau were significantly lower than those at baseline (P = 0.001, P = 0.012, and P = 0.034). Conclusions: These findings indicate that peripheral blood levels of neuronal-derived exosomal A beta and tau proteins were increased in OSA patients with cognitive impairment. CPAP interventions could possibly improve cognitive function and be associated with decreased levels of exosomal A beta and tau proteins. (C) 2022 Elsevier B.V. All rights reserved.
NSTL
Elsevier
