首页|Pregnane glycosides from Adonis amurensis and their bioactivity

Pregnane glycosides from Adonis amurensis and their bioactivity

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  • NSTL
  • Elsevier
Seven undescribed pregnane glycosides named amurensides A-G and two known aglycones were isolated from the whole herb of Adonis amurensis Regel & Radde. Their structures were established based on 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and acid hydrolysis. The cytotoxicity of all compounds against three tumor cell lines (HepG2, Caco-2, and A549) were evaluated. Among them, amurensides A-C and E showed moderate inhibitory effects on the growth of HepG2 cells, with IC50 values ranging from 15.6 to 48.7 mu M (sorafenib, 7.5 +/- 1.9 mu M). Amurensides A, D and F displayed inhibitory effects on the growth of A549 cells with IC50 values of 18.8 +/- 1.2, 12.4 +/- 0.6, and 30.4 +/- 0.1 mu M (cis-platinum, 6.1 +/- 0.1 mu M), respectively.

Adonis amurensis Regel & raddeRanunculaceaeStructure elucidationPregnane glycosidesCytotoxicityC-21 STEROIDAL GLYCOSIDESROOTSCONSTITUENTS

Yan, Yue、Zhou, Di、Li, Xuezheng、Feng, Yuan、Wen, Xiaoyan、Wang, Yajun、An, Renbo、Chen, Gang、Li, Ning

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Shenyang Pharmaceut Univ

Yanbian Univ Hosp

Yanbian Univ

2022

10.1016/j.phytochem.2021.113046

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.194
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