Abstract
Seven undescribed pregnane glycosides named amurensides A-G and two known aglycones were isolated from the whole herb of Adonis amurensis Regel & Radde. Their structures were established based on 1D and 2D NMR spectroscopic analyses, high-resolution mass spectrometry, and acid hydrolysis. The cytotoxicity of all compounds against three tumor cell lines (HepG2, Caco-2, and A549) were evaluated. Among them, amurensides A-C and E showed moderate inhibitory effects on the growth of HepG2 cells, with IC50 values ranging from 15.6 to 48.7 mu M (sorafenib, 7.5 +/- 1.9 mu M). Amurensides A, D and F displayed inhibitory effects on the growth of A549 cells with IC50 values of 18.8 +/- 1.2, 12.4 +/- 0.6, and 30.4 +/- 0.1 mu M (cis-platinum, 6.1 +/- 0.1 mu M), respectively.
NSTL
Elsevier