Palladium-catalyzed borylation of aryl bromides and chlorides using phosphatrioxa-adamantane ligands
Lamola, Jairus L. 1Moshapo, Paseka T. 1Holzapfel, Cedric W. 1Maumela, Munaka Christopher1
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作者信息
1. Univ Johannesburg
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Abstract
Catalysts based on the combination of Pd(OAc)(2) and the electron-deficient phosphatrioxa-adamantane ligands are described for borylation of aryl bromides and chlorides. Catalytic evaluation of a small library of phosphatrioxa-adamantane ligands provided some insights on the preferred ligand steric profile for borylation reactions. The corresponding aryl boronate esters were accessed under mild conditions (25-70 degrees C) and isolated in high yields (up to 96%). (C) 2021 Elsevier Ltd. All rights reserved.
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Elsevier