首页|Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection
Rise and exacerbation of oral lichen planus in the background of SARS-CoV-2 infection
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NSTL
Oral Lichen Planus (OLP) is a chronic inflammatory disorder whose exact etiology remains unknown。 Inflammatory mediators， cytotoxic CD8+ T cells and mast cells have been hypothesized to mediate the pathogenesis of OLP。 COVID-19 pandemic caused by SARS-CoV-2 is marked by cytokine storms in the affected patients。 Altered T-cell responses marked by exhaustion of T-cell count with hyperaggressive remaining T-cells and presence of cross-reactive antibodies render infected humans as fertile grounds for development of multisystem disorders。 In addition， Vitamin D deficiency in COVID-19 patients can further modify the T cell mediated immunity。 Increased circulating cytokines and hyperactive CD8+ T cells can alter the oral immune barriers rendering them susceptible to oral disorders。 Due to the widespread immune dysregulation， it is possible that patients of COVID-19 may develop OLP in the aftermath or during recovery。 The paper explores the pathogenic mechanism behind development OLP as post-COVID condition on account of their target receptor， T-cell responses， cytokine profile， mucosal immune barriers and nutrition deficiency。
NSTL
