Succinate dehydrogenase (SDH) is extremely important in metabolic function and biological processes. Modulationof SDH has been reported to be a promising therapeutic target to SDH mutations. Current measures for the regulation of SDH arescarce, and precise and reversible modulation of SDH still remains challenging. Herein, a powerful tool for reversible optical controlof SDH was proposed and evaluated utilizing the technology of photopharmacology. We reported photochromic ligands (PCLs),azobenzene-pyrazole amides (APAs), that exert light-dependent inhibition effects on SDH. Physicochemical property tests andbiological assays were conducted to demonstrate the feasibility of modulating SDH. In this paper, common agricultural pathogenswere used to develop a procedure by which our PCLs could reversibly and precisely control SDH utilizing green light. This researchwould help us to understand the target-ligand interactions and provide new insights into modulation of SDH.
NSTL
Amer Chemical Soc