首页|Photometric Determination of Novocaine with Preconcentration in Surfactant Micelles
Photometric Determination of Novocaine with Preconcentration in Surfactant Micelles
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NSTL
Pleiades Publishing Inc
The work deals with the extraction and preconcentration of novocaine using mixed surfactants of nonionic (Triton X-114) and anionic (sodium dodecyl sulfate) types with the photometric registration of an analytical signal. The method is based on the condensation reaction of novocaine with p-dimethylaminobenzaldehyde (pH 2.5-3.5) and the subsequent micellar extraction of the colored analytical form, the Schiff base. For the effective extraction of this form, the parameters of micellar extraction (concentrations of reagents: c(NaCl) = 0.5-1 \M, c(Triton X-114) = 2 x 10(-3)-1 x 10(-2) M; conditions: centrifugation time 5 min at 3000 rpm) are optimized. The proposed method makes it possible to determine novocaine in the concentration range 38-4800 ng/mL (RSD <= 7%, limit of detection 19 ng/mL), which is several orders of magnitude lower than in the known spectrophotometric versions. The Bouguer-Lambert-Beer law is obeyed in the range 8 x 10(-7)-4 x 10(-5) M. The developed extraction-photometric method was tested in the determination of novocaine in 0.5% ampoule solutions for injection.
NSTL
Pleiades Publishing Inc
