首页|Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1 <ce:italic>S</ce:italic>,2 <ce:italic>R</ce:italic>)-tranylcypromine
Amidation of carboxylic acids via the mixed carbonic carboxylic anhydrides and its application to synthesis of antidepressant (1 <ce:italic>S</ce:italic>,2 <ce:italic>R</ce:italic>)-tranylcypromine
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NSTL
Elsevier
<![CDATA[<ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" xmlns="http://www.elsevier.com/xml/ja/dtd" class="graphical" xml:lang="en" id="ab005" view="all"><ce:section-title id="st005">Graphical abstract</ce:section-title><ce:abstract-sec id="as005" view="all"><ce:simple-para>Display Omitted</ce:simple-para></ce:abstract-sec></ce:abstract><ce:abstract xmlns:ce="http://www.elsevier.com/xml/common/dtd" xmlns="http://www.elsevier.com/xml/ja/dtd" class="author" xml:lang="en" id="ab010" view="all"><ce:section-title id="st010">Abstract</ce:section-title><ce:abstract-sec id="as010" view="all"><ce:simple-para id="sp0010" view="all">Primary amidations of carboxylic acids<ce:bold>1</ce:bold>or<ce:bold>3</ce:bold>with NH<ce:inf loc="post">4</ce:inf>Cl in the presence of ClCO<ce:inf loc="post">2</ce:inf>Et and Et<ce:inf loc="post">3</ce:inf>N were developed to afford the corresponding primary amides in 22% to quantitative yields. Additionally, we have applied the amidation to the preparation of various amides containing hydroxamic acids and achieved the synthesis of (1<ce:italic>S</ce:italic>,2<ce:italic>R</ce:italic>)-tranylcypromine as an antidepressant medicine via Lossen rearrangement.</ce:simple-para></ce:abstract-sec></ce:abstract>]]>
NSTL
Elsevier
