首页|The NF-kappa B inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses

The NF-kappa B inhibitor, SC75741, is a novel antiviral against emerging tick-borne bandaviruses

扫码查看
原文链接
  • NSTL
  • Elsevier
Severe fever with thrombocytopenia syndrome virus (SFTSV) and Heartland virus (HRTV) cause viral hemorrhagic fever-like illnesses in humans due to an aberrant host inflammatory response, which contributes to pathogenesis. Here, we established two separate minigenome (MG) systems based on the M-segment of SFTSV and HRTV. Following characterization of both systems for SFTSV and HRTV, we used them as a platform to screen potential compounds that inhibit viral RNA synthesis. We demonstrated that the NF-kappa B inhibitor, SC75741, reduces viral RNA synthesis of SFTSV and HRTV using our MG platform and validated these results using infectious SFTSV and HRTV. These results may lead to the use of MG systems as potential screening systems for the identification of antiviral compounds and yield novel insights into host-factors that could play role in bandavirus transcription and replication.

BandavirusSevere fever with thrombocytopenia syndromevirusHeartland virusAntiviralAnd minigenome

Mendoza, Crystal A.、Yamaoka, Satoko、Tsuda, Yoshimi、Matsuno, Keita、Weisend, Carla M.、Ebihara, Hideki

展开 >

Mayo Clin, Grad Sch Biomed Sci, Rochester, MN 55905 USA

Mayo Clin, Dept Mol Med, Rochester, MN 55905 USA

Hokkaido Univ, Fac Med, Dept Microbiol & Immunol, Sapporo, Hokkaido 0608638, Japan

Hokkaido Univ, Unit Risk Anal & Management, Res Ctr Zoonosis Control, Sapporo, Hokkaido 0010020

展开 >

2021

10.1016/j.antiviral.2020.104993

Antiviral research.

Antiviral research.

ISSN：0166-3542
年,卷(期)：2021.185
  • 5
  • 62