Tetrahedron letters2022，Vol.1005.DOI:10.1016/j.tetlet.2022.153882

Synthesis of functionalized flavones from 3-halo-2-(methylthio)-4H-chromen-4-ones

Elagamy, Amr Elghoneimy, Laila K. Arafa, Reem K. Pratap, Ramendra
Tetrahedron letters2022，Vol.1005.DOI:10.1016/j.tetlet.2022.153882
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  • NSTL
  • Elsevier

Synthesis of functionalized flavones from 3-halo-2-(methylthio)-4H-chromen-4-ones

Elagamy, Amr 1Elghoneimy, Laila K. 2Arafa, Reem K. 2Pratap, Ramendra1
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作者信息

  • 1. Univ Delhi
  • 2. Zewail City Sci & Technol
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Abstract

A simple and efficient method for the synthesis of flavones was achieved by selective sulfide LiebeskindSrogl cross-coupling reaction of 2-(methylthio)-4H-chromen-4-ones and 3-halo-2-(methylthio)-4H-chromen-4-ones with arylboronic acids. This method is the first example of employing Liebeskind-Srogl coupling for the synthesis of flavones. Various aryl groups can be directly installed to the chromone ring. The structure of all the synthesized compounds were assigned by spectroscopic analysis. (C) 2022 Elsevier Ltd. All rights reserved.

Key words

4H-chromen-4-ones/Flavones/Cross-coupling/GSK-3 beta inhibitor/GLYCOGEN-SYNTHASE KINASE-3/EFFICIENT SYNTHESIS/DERIVATIVES/CHROMONES/CANCER/ACTIVATION/ANNULATION/FLAVOPIRIDOL/INHIBITORS/ARYLATION

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量48
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