Fitoterapia2022，Vol.15712.DOI:10.1016/j.fitote.2022.105139

Euphzycopias A-I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L.

Zhang, Yu Xiong, Feng Zhang, Jing-Jing Yue, Chen-Fang Bi, De-Wen Cheng, Bin Wu, Xue-Wen Li, Qing Zhang, Xing-Jie Zhang, Rui-Han Dai, Xiao-Chang Shi, Qiang-Qiang Xiao, Wei-Lie Li, Xiao-Li
Fitoterapia2022，Vol.15712.DOI:10.1016/j.fitote.2022.105139
✕
  • NSTL
  • Elsevier

Euphzycopias A-I, macrocyclic diterpenes with NLRP3 inflammasome inhibitory activity from Euphorbia helioscopia L.

Zhang, Yu 1Xiong, Feng 1Zhang, Jing-Jing 1Yue, Chen-Fang 1Bi, De-Wen 1Cheng, Bin 1Wu, Xue-Wen 1Li, Qing 1Zhang, Xing-Jie 1Zhang, Rui-Han 1Dai, Xiao-Chang 1Shi, Qiang-Qiang 1Xiao, Wei-Lie 1Li, Xiao-Li1
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作者信息

  • 1. Yunnan Univ
  • 折叠

Abstract

A phytochemical investigation was conducted on Euphorbia helioscopia, resulting in the isolation of thirteen compounds, including nine undescribed diterpenoids, Euphzycopias A - I (1-9), of which the skeletons of compounds 1-4 were found in E. helioscopia L. Compounds 1-3 had 5/7/6 cyclic systems, while compound 4 had a 4/11 polycyclic system with a 4,7-cyclic ether between C-4 and C-7. The anti-inflammasome test using the isolated compounds (1-6, 8-13) showed that the diterpenes from E. helioscopia L. had a strong inhibitory effect on NLRP3 inflammasomes with IC50 values of 3.34-14.92 mu M.

Key words

Euphorbia helioscopia L./Euphorbiaceae/Diterpenoids/NLRP3 inflammasome

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出版年

2022
Fitoterapia

Fitoterapia

SCI
ISSN：0367-326X
被引量5
参考文献量30
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