2. Indiana Univ, Dept Chem, Bloomington, IN 47405 USA
3. Northwestern Univ, Dept Chem, 2145 Sheridan Rd, Evanston, IL 60208 USA
折叠
Abstract
Ion mobility spectrometry was utilized to corroborate the identity of streptorubin B (2) as the natural product produced by Streptomyces coelicolor. Natural product 2 was initially assigned as butylcycloheptylprodigiosin (3), and only relatively recently was this assignment clarified. We present additional evidence of this assignment by comparing collisional cross sections (Omega) of synthetic standards of 2, 3, and metacycloprodigiosin (4) to the cyclic prodiginine produced by S. coelicolor. Calculated theoretical Omega values demonstrate that cyclic prodiginines could be identified without standards. This work highlights ion mobility as an efficient tool for the dereplication of natural products.
NSTL
Amer Chemical Soc