首页|Identification of a novel anticancer mechanism of Paeoniae Radix extracts based on systematic transcriptome analysis
Identification of a novel anticancer mechanism of Paeoniae Radix extracts based on systematic transcriptome analysis
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NSTL
Paeoniae Radix (PR) has a great therapeutic value in many clinical applications; however， the presence of various bioactive compounds and its complicated effects on human health makes its precise mechanisms of action unclear。 This study investigated the effects of PR at the molecular pathway level by profiling genome-wide gene expression changes following dose-dependent treatment of human lung cancer cells (A549) with PR water extract (WPR)， PR ethanol extracts (EPR)， as well as their individual components。 We found that PR exerts anticancer effects in A549 cells by regulating numerous pathways。 Specifically， EPR and two compounds， namely， heder-agenin (HG) and oleanolic acid (OA)， significantly downregulate the Aurora B pathway。 Furthermore， we generated an integrated PR extracts-compounds-target genes network in the Aurora B pathway to understand their interactions。 Our findings reinforce that inhibiting Aurora kinase activity is a therapeutic target for treating cancers， providing the potential for novel mechanisms of action for PR and its components against lung cancer。
Lung cancerPaeoniae RadixAurora B pathwayTranscriptome
Haeseung Lee、Sang-Min Park、Musun Park、Jin-Mu Yi、No Soo Kim、Aeyung Kim、Seongwon Cha、Su-Jin Baek
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Korean Medicine (KM) Data Division, Korea Institute of Oriental Medicine, Daejeon 34054, Republic
NSTL
