首页|Polymer nanotherapeutics to correct autoimmunity

Polymer nanotherapeutics to correct autoimmunity

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  • NSTL
  • Elsevier
The immune system maintains homeostasis and protects the body from pathogens, mutated cells, and other harmful substances. When immune homeostasis is disrupted, excessive autoimmunity will lead to diseases. To inhibit the unexpected immune responses and reduce the impact of treatment on immunoprotective functions, polymer nanotherapeutics, such as nanomedicines, nanovaccines, and nanodecoys, were developed as part of an advanced strategy for precise immunomodulation. Nanomedicines transport cytotoxic drugs to target sites to reduce the occurrence of side effects and increase the stability and bioactivity of various immunomodulating agents, especially nucleic acids and cytokines. In addition, polymer nanomaterials carrying autoantigens used as nanovaccines can induce antigen-specific immune tolerance without interfering with protective immune responses. The precise immunomodulatory function of nanovaccines has broad prospects for the treatment of immune related-diseases. Besides, nanodecoys, which are designed to protect the body from various pathogenic

Polymer nanotherapeuticAutoimmune diseaseHypersensitivityTransplant rejectionImmunomodulationADJUVANT-INDUCED ARTHRITIST-CELL ACTIVITYRHEUMATOID-ARTHRITISIN-VIVOMULTIPLE-SCLEROSISIMMUNE TOLERANCENANOPARTICLE TECHNOLOGYALBUMIN NANOPARTICLESLOADED NANOPARTICLESCPG IMMUNOTHERAPY

Su, Tianqi、Feng, Xiangru、Yang, Jiazhen、Xu, Weiguo、Liu, Tongjun、Zhang, Minglei、Ding, Jianxun、Chen, Xuesi

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Second Hosp Jilin Univ

Changchun Univ Sci & Technol

Chinese Acad Sci

China Japan Union Hosp Jilin Univ

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2022

10.1016/j.jconrel.2021.12.036

Journal of Controlled Release

Journal of Controlled Release

EISCI
ISSN：0168-3659
年,卷(期)：2022.343
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