Simple, green and one pot new strategy for synthesis of the phthalimide derivatives
Moazzam, Ali 1Hosseini, Samanesadat 1Larijani, Bagher 1Gholami, Fatemeh 2Adib, Mehdi 2Mahdavi, Mohammad1
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作者信息
1. Univ Tehran Med Sci
2. Univ Tehran
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Abstract
A novel, simple, green, one pot and practical synthetic method is described for the preparation of phthalimide derivatives through a condensation reaction between of 2-formylbenzoic acid and aniline in the presence of Et3N as base and S-8 (Octasulfur) as oxidant in solvent free condition. This one-pot protocol provides these valuable desired compounds under mild conditions with excellent efficiency by using simple available starting materials. (C) 2022 Elsevier Ltd. All rights reserved.
Key words
One pot/Solvent Free/Phthalimide/PALLADIUM-CATALYZED CARBONYLATION/ELEMENTAL SULFUR/CYCLIC IMIDES/ANTIINFLAMMATORY ACTIVITY/BOND FORMATION/THALIDOMIDE/EFFICIENT/AMINES/HYDROLYSIS/KETONES