首页|Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies
Dark genome, bright ideas: Recent approaches to harness transposable elements in immunotherapies
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NSTL
Transposable elements (TEs), which make up almost half of the human genome, often display altered expression in cancers. Here, we review recent progress in elucidating the role of TEs as mediators of immune responses in cancer and discuss how novel therapeutic strategies can harness TE immunogenicity for cancer immunotherapy. Transposable elements (TEs) are current or previous mobile elements within the genome. In humans, they constitute 46% of the genome and are classified into two main types: DNA transposons and retroelements. Retroelements are further divided into three broad subclasses: long interspersed nuclear elements (LINEs), short interspersed nuclear elements (SINEs), and long terminal repeat (LTR)/endogenous retrovirus (ERV) elements (Figure 1A).
Ashley Reid Cahn、Nina Bhardwaj、Nicolas Vabret
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Tisch Cancer Institute, Precision Immunology Institute, Department of Medicine, Hematology and
NSTL
