Abstract
The present work has considered designing bioactive and biocidal coatings to address the unsatisfactory performance of implanted medical devices due to microbial contamination. The non-leaching biocidal polyurethanesiloxane coating was fabricated through the sol-gel reaction of monocomponent soybean oil prepolymer containing the reactive alkoxysilane, quaternary ammonium, and urethane moieties (Si-PPU) on a model metallic substrate. The Si-PPU prepolymer was prepared by three-step synthesis, including the carbonation of ESBO with CO2, urethane formation through the non-isocyanate approach, and simultaneous quaternization, and alkoxysilane functionalization. The adhesion strength of about 2.75 MPa to an aluminum plate, high pendulum hardness (254 s(-1)), superior flexibility, and high impact resistance could meet biomedical coating applications' requirements. The superior contact-active biocidal activity towards Gram-negative and Gram-positive bacteria was provided by prepared coating. Meanwhile, no evidence for cytotoxicity was observed, and the coating presented favorable cell adhesion and proliferation. The high cell viability (> 90%) and low hemolysis rate (HR < 1%) confirmed the cytocompatibility of coatings.
NSTL
Elsevier