首页|Fast Ion-Beam Inactivation of Viruses, Where Radiation Track Structure Meets RNA Structural Biology
Fast Ion-Beam Inactivation of Viruses, Where Radiation Track Structure Meets RNA Structural Biology
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NSTL
Radiation Research Soc
Here we show an interplay between the structures present in ionization tracks and nucleocapsid RNA structural biology, using fast ion-beam inactivation of the severe acute respiratory syndrome coronavirus (SARS-CoV) virion as an example. This interplay could be a key factor in predicting dose-inactivation curves for high-energy ion-beam inactivation of virions. We also investigate the adaptation of well-established cross-section data derived from radiation interactions with water to the interactions involving the components of a virion, going beyond the density-scaling approximation developed previously. We conclude that solving one of the grand challenges of structural biology-the determination of RNA tertiary/ quaternary structure-is linked to predicting ion-beam inactivation of viruses and that the two problems can be mutually informative. Indeed, our simulations show that fast ion beams have a key role to play in elucidating RNA tertiary/quaternary structure. (C) 2022 by Radiation Research Society
CORONAVIRUS NUCLEOCAPSID PROTEINELECTRONMODEL
Villagomez-Bernabe, B.、Chan, S. W.、Coulter, J. A.、Roseman, A. M.、Currell, F. J.
NSTL
Radiation Research Soc
