首页|Induction of funitatin A, a new polyketide from the Yellow River wetland-derived fungus Talaromyces funiculosus

Induction of funitatin A, a new polyketide from the Yellow River wetland-derived fungus Talaromyces funiculosus

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  • NSTL
  • Elsevier
? 2021 Phytochemical Society of EuropeA new, highly modified fatty acid ester, funitatin A (1), was isolated from the Yellow River wetland-derived fungus Talaromyces funiculosus HPU-Y01 cultivated with the histone deacetylase inhibitor suberoylanilide hydroxamic acid (SAHA). The structure of 1 was established by analysis of NMR and HRESIMS data. Compound 1 featured a rare dimeric cyclopaldic acid structure and showed promising antimicrobial activity against both Proteus species and Escherichia coli with MIC values of 3.13 μM.

Antimicrobial activityCyclopaldic acidEpigenetic modificationSecondary metaboliteTalaromyces funiculosusYellow River wetland-derived fungus

Wang Z.、He X.、Niu C.、Zhang Z.、Zhou J.

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College of Medicine Henan Polytechnic University

Beijing Bencaoyuan Pharmaceutical Co. Ltd

2022

10.1016/j.phytol.2021.11.003

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
  • 19