Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153573

Stereoselective desymmetrizations of dinitriles to synthesize lactones

Kelley, Amber M. Frost, Joshua A. Baber, Tylisha M. Youngblood, Kala C. Michishita, Emiri Bain, Schuyler A. Lykins, T. Caleb Petersen, Kimberly S.
Tetrahedron letters2022，Vol.884.DOI:10.1016/j.tetlet.2021.153573
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  • NSTL
  • Elsevier

Stereoselective desymmetrizations of dinitriles to synthesize lactones

Kelley, Amber M. 1Frost, Joshua A. 1Baber, Tylisha M. 1Youngblood, Kala C. 1Michishita, Emiri 1Bain, Schuyler A. 1Lykins, T. Caleb 1Petersen, Kimberly S.1
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作者信息

  • 1. Univ North Carolina Greensboro
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Abstract

Nitriles are important organic functional groups, allowing for installation of nitrogen in organic synthesis. The Pinner reaction transforms nitriles into esters via the imidate group, but in general has previously necessitated harsh acid conditions. This work builds on the utility of the Pinner reaction through a stereoselective desymmetrization of dinitriles to form gamma- and delta-lactones in good yields and diastereoselectivites. (C) 2021 Elsevier Ltd. All rights reserved.

Key words

Pinner Reaction/Desymmetrization/Diastereoselective/Lactones/PINNER REACTION/DELTA-LACTONE

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
参考文献量15
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