首页|Cytotoxic sesquiterpenoids from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark

Cytotoxic sesquiterpenoids from Dysoxylum parasiticum (Osbeck) Kosterm. stem bark

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  • NSTL
  • Elsevier
? 2021 Phytochemical Society of EuropeTwo undescribed sesquiterpenoid derivatives, 10β,11-dihydroxy-1β-hydroperoxide-4αH,5αH,7βH-guaiane (1) and 10β-hydroxy-4α,4β-dimethyl-5αH,7αH-eudesm-3-one (2) along with three known of guaiane, aromadendrane, and cadinane sesquiterpenoids (3-5) were isolated from the stem bark of Dysoxylum parasiticum (Osbeck) Kosterm. The chemical structure of the compounds were determined by detailed analysis of spectroscopic data, including MS, IR, 1D, and 2D NMR as well as through comparison with data of known analogues. The isolated compounds were also tested for cytotoxic properties against MCF-7 breast cancer line. Compound 4, was found to exhibit the strongest cytotoxic activity with an IC50 value of 12.17 μM, while the other compounds showed moderate or no activity.

Cytotoxic activityDysoxylum parasiticumMCF-7 cell lineMeliaceaeSesquiterpenoids

Arofatusnaini A.、Mayanti T.、Nurlelasari、Harneti D.、Maharani R.、Safari A.、Hidayat A.T.、Farabi K.、Supratman U.、Lesmana R.、Shiono Y.

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Department of Chemistry Faculty of Mathematics and Natural Sciences Universitas Padjadjaran

Physiology Division Department of Biomedical Sciences Faculty of Medicine Universitas Padjadjaran

Department of Food Life and Environmental Science Faculty of Agriculture Yamagata University

2022

10.1016/j.phytol.2021.11.010

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
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