首页|Transient perivascular inflammation of the carotid artery (TIPIC) syndrome.

Transient perivascular inflammation of the carotid artery (TIPIC) syndrome.

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<i>Background : The Transient Perivascular Inflammation of the Carotid artery (TIPIC) syndrome is presumably a very rare disease characterized by a local transient inflammation of the tissue around the carotid artery. Its pathophysiology remains unknown. We performed an updated study of TIPIC syndrome cases in the setting of a multinational collaborative study.<i>Methods : This study was conducted as an observational multinational retrospective individual patient level cohort study. Information from all known cases diagnosed with TIPIC syndrome in the literature (2005-2020) was collected after a semi-structured literature search of PubMed and Web of Science. We also collected unpublished information of patients from French, Swiss, and Italian vascular medicine or radiology departments.<i>Results : A total of 72 patients were included and served for data analysis: 42 (58.3%) were women; the mean age was 47.9 (SD=11.4) years. Symptoms were unilateral in 92% of patients and 81.4% required pain killers. At baseline, irrespective of the imaging method used, the median thickness of the carotid lesions was 5 (Q1-Q3: 4-7; range: 2-11) mm and the median length of the lesion was 20 (Q1-Q3: 10-30; range: 3-50) mm. We found a positive linear correlation between thickness and length. At follow-up, the thickness of the carotid lesions decreased to a median of 2 (Q1-Q3: 1-3; range: 0-6) mm; the length decreased to a median 10 (Q1-Q3: 5-15; range: 0-41) mm. A linear correlation between baseline and follow-up values was observed for both thickness and length measurements. Symptoms disappeared after a median of 14 (Q1-Q3: 10-15) days. Thirteen patients experienced a recurrence after a median follow-up of 6 (Q1-Q3: 2-12) months.<i>Conclusions : The present analysis elucidates clinical and sonographic characteristics of TIPIC syndrome, indicating the benign nature of this condition. A future international registry will study the long-term course of the disease.

CarotidyniaTIPIC syndromefay syndromeperivascular inflammationcarotid artery

Nicola Mumoli、Daniela Mastroiacovo、Alexandru Grigorean、Michael Obadia、Nicolas Menjot de Champfleur、Olivier Naggara、Béatrice Carsin、Malika Amor-Sahli、Jean Philippe Cottier、Jérémie Bensoussan、Elisabeth Auffray-Calvier、Arthur Varoquaux、Fabrice Bonneville、Jean Claude Sadik、Nils Kucher、Augustin Lecler、Stefano Barco、Evy Micieli、Davide Voci

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Department of Internal Medicine, Magenta Hospital, Magenta (MI)

Angiology Unit, SS Filippo and Nicola Hospital, Avezzano (AQ)

Department of Angiology, University Hospital Zurich

Department of Neurology, A.Rothschild Foundation Hospital

Department of Neuroradiology, CHU Montpellier

Department of Neuroradiology, CHU Sainte Anne

Department of Neuroradiology, CHU Rennes

Department of Neuroradiology, CHU La Pitié-Salpêtrière

Department of Neuroradiology, CHU Tours

Department of Neuroradiology, CHU H?tel Dieu

Department of Neuroradiology, CHU Nantes

Department of Neuroradiology, CHU Marseille

Department of Neuroradiology, CHU Toulouse

Department of Neuroradiology, A.Rothschild Foundation Hospital

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2022

10.1024/0301-1526/a000989

VASA.

VASA.

ISSN：0301-1526
年,卷(期)：2022.51(2)
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