首页|Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c
Human placenta and trophoblasts simultaneously express three isoforms of atypical protein kinase-c
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NSTL
Elsevier
Atypical protein kinase-c (aPKC) isoforms are important regulators of polarity and stem cell differentiation. There are three isoforms of aPKC: aPKC-iota, aPKC-zeta, and PKM-zeta. Recently, aPKC-iota was shown to regulate human trophoblast stem cell (TSC) differentiation. Compensation by remaining isoforms when a single aPKC isoform is lost can occur, but the expression pattern of aPKC-zeta in placenta is unknown. Here we show that aPKC-iota, aPKC-zeta and a new isoform, aPKC-zeta III, are expressed in trophoblasts. Therefore, studies examining the role of aPKC isoforms that control for potential compensation between aPKC isoforms are necessary to understand aPKCmediated regulation of TSC differentiation.
PlacentaTrophoblastAtypical protein kinase-cTrophoblast stem cells
NSTL
Elsevier
