New iridal-type triterpenoid analogues with 6/5/6-fused carbon skeleton from the rhizomes of Belamcanda chinensis
Li, Jiayuan 1Ni, Gang 1Liu, Yanfei 1Wang, Renzhong 1Yu, Dequan1
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作者信息
1. Chinese Acad Med Sci & Peking Union Med Coll
折叠
Abstract
Five new iridal-type triterpenoid derivatives with 6/5/6 tricyclic ring skeleton (1-5) were obtained from the rhizomes of Belamcanda chinensis. Their structures were determined on the basis of detailed spectroscopic data and ECD calculation. Compounds 1-5 possessed the same 6/5/6-fused carbon skeleton as Belamchinenin A, which further enriched this kind of iridals. In vitro bioassay, compounds 2 and 3 exhibited 51.95 and 54.52% inhibitory activities, respectively, against Fe2+/cysteine-induced liver microsomal lipid peroxidation at a concentration of 10 mu M. A putative biogenetic pathway for compounds 1-5 was proposed.
Key words
B. chinensis/Iridal-type triterpenoids/6/5/6-fused tricyclic scaffold/Antioxidant activity/IRIS/POLYCYCLOIRIDALS
NSTL
Elsevier