首页|Specification of hematopoietic stem cells in mammalian embryos: a rare or frequent event?
Specification of hematopoietic stem cells in mammalian embryos: a rare or frequent event?
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NSTL
Amer Soc Hematology
Hematopoietic stem cells (HSCs) are the blood-forming stem cells thought to be responsible for supporting the blood system throughout life. Transplantability has long been the flagship assay used to define and characterize HSCs throughout ontogeny. However, it has recently become clear that many cells emerge during ontogeny that lack transplantability yet nevertheless are fated to ultimately contribute to the adult HSC pool. Here, we explore recent advances in understanding the numbers and kinetics of cells that emerge during development to support lifelong hematopoiesis; these advances are made possible by new technologies allowing interrogation of lifelong blood potential without embryo perturbation or transplantation. Illuminating the dynamics of these cells during normal development informs efforts to better understand the origins of hematologic disease and engineer HSCs from differentiating pluripotent stem cells. ? 2022 American Society of Hematology
Ganuza M、Clements W、McKinney-Freeman S
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Centre for Haemato-Oncology, Barts Cancer Institute, Queen Mary University of London, London
NSTL
Amer Soc Hematology
