首页|The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.
The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.
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NSTL
Numerous reports link oxidative stress to particulate matter (PM)-induced adverse health effects. Increasing evidence is being collected that reactive oxygen species and oxidative stress are involved in PM-mediated injury. The physical characteristics and the chemical composition of PM play a key role in reactive oxygen species generation in vitro and in vivo. According to the hierarchical oxidative stress hypothesis, antioxidant phase II enzymes protect against PM-induced inflammation and cytotoxicity. This concept is useful in understanding PM-induced disease models, susceptibility, and biomaker development to access exposures outcomes and is useful for developing therapeutic intervention in PM-induced adverse health effects.
Oxidative StressReactive Oxygen SpeciesInjury inflicted to the body by an external force氧化性应激活性氧组分角色卫生
Xia T、Kovochich M、Nel A
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Division of Clinical Immunology and Allergy, Department of Medicine, University of California Los Angeles, 52-175 CHS, Los Angeles, CA 90095-1680, USA.
2006
Clinics in Occupational and Environmental Medicine
NSTL
