首页|Three new compounds isolated from the bulbs of Fritillaria pallidiflora Schrenk and their anti-inflammatory activity

Three new compounds isolated from the bulbs of Fritillaria pallidiflora Schrenk and their anti-inflammatory activity

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  • NSTL
  • Elsevier
? 2021Three new compounds, 17β-cevanin-6-oxo-5α,20β-diol yibeinine (1), 2-(tetrahydro-5-(2-hydroxyphenyl)-2H-pyran-3-yl) phenol (2), 1,3-O-diferuloyl-2-methoxypropane diol (3), as well as four known compounds (4–7), have been isolated from the ethanol extract of dried bulbs of Fritillaria pallidiflora Schrenk. All structures were determined based on their spectroscopic data (1D and 2D NMR (including 1H NMR, 13C NMR, 1H-1H COSY, HMBC, HSQC, HSQC-TOCSY, and NOESY experiments), and MS). Biological evaluation showed that compounds 1–4 inhibited the production of nitric oxide (NO) in LPS-stimulated RAW 264.7 cells with IC50 values of 18.0, 38.7, 29.5, and 47.1 μM, respectively. These results indicated that compound 1 has potential anti-inflammatory activity.

AlkaloidsAnti-inflammatory activityFritillaria pallidiflora SchrenkIsosteroidal alkaloidsPhenylpropionic acid derivatives

Zhang J.、Ma G.-X.、Wei H.-Y.、Xu X.-Q.、Guan Y.-Q.、Shi L.-L.、Zhang M.-L.、Si Y.

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College of Chinese Medicine Material Jilin Agricultural University

Xinjiang Institute of Chinese and Ethnic Medicine

2022

10.1016/j.phytol.2021.11.007

Phytochemistry Letters

Phytochemistry Letters

SCI
ISSN：1874-3900
年,卷(期)：2022.47
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