首页|The fluorescence properties of 4'-Methoxy chalcone derivates modified by substituents and investigation of lysosomal imaging
The fluorescence properties of 4'-Methoxy chalcone derivates modified by substituents and investigation of lysosomal imaging
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NSTL
Three types of 4'-methoxychalcone derivatives Cha-1 ~ Cha-9 with different electron-withdrawing or electron-donating substituents at different positions were synthesized and studied. When the A ring has a hydroxyl group at the 2-position, the strong electron-donating groups at the 4-position of the B ring was more conducive to the near-infrared and aggregation-enhanced emission (AEE) features of the compound than the electron withdrawing groups. The single-crystal analysis confirmed that the good planarity of the 4'-methoxychalcone derivatives favors their fluorescence quantum yields. Moreover, chalcone fluorophores with different fluorescence properties could be obtained by modulating substituent at the 2-position of A ring. In addition, Cha-9 was selected as the AEE luminogen to locate the lysosomes in HeLa cells. These results provided fundamental knowledge for the design and application of 4'-methoxychalcone derivatives of aggregation-induced emission (AIE) compounds.
Beijing Key Laboratory of Construction Tailorable Advanced Functional Materials and Green Applications, School of Material Science & Engineering, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, China
NSTL
