Tumour biology2015，Vol.36Issue(8) ：7.DOI:10.1007/s13277-015-3336-z

Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma

Wang, Zhixin Qu, Kai Huang, Zhichao Xu, Xinsen Zhang, Jingyao Zhang, Li Liu, Sinan Chang, Hulin Lin, Ting Liu, Yamin Niu, Wenquan Liu, Chang
Tumour biology2015，Vol.36Issue(8) ：7.DOI:10.1007/s13277-015-3336-z
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Glutathione S-transferase O2 gene rs157077 polymorphism predicts response to transarterial chemoembolization in hepatocellular carcinoma

Wang, Zhixin 1Qu, Kai 1Huang, Zhichao 1Xu, Xinsen 1Zhang, Jingyao 1Zhang, Li 2Liu, Sinan 1Chang, Hulin 1Lin, Ting 1Liu, Yamin 3Niu, Wenquan 4Liu, Chang1
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作者信息

  • 1. Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Hepatobiliary Surg, Xian 710061, Shaanxi
  • 2. Fourth Mil Med Univ, Tangdu Hosp, Dept Ultrasound Diagnost, Xian 710038, Shaanxi Provinc, Peoples R
  • 3. Xi An Jiao Tong Univ, Coll Med, Affiliated Hosp 1, Dept Cardiol & Periphery Vasc Med, Xian 710061
  • 4. Shanghai Jiao Tong Univ, Sch Med, Ruijin Hosp, State Key Lab Med Genom, Shanghai 200025, Peoples R
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Abstract

Some genetic alterations of glutathione S-transferase omega 2 (GSTO2) have been reported to increase the risk of many malignancies, including hepatocellular carcinoma (HCC); however, their prognostic capability remained unresolved in HCC patients treated with transarterial chemoembolization (TACE). To fill this gap, we genotyped three well-defined polymorphisms in GSTO2 to assess whether they can predict overall survival among 228 HCC patients under TACE treatment. The median follow-up time and survival time were 22.0 months (range 3.0-60.0) and 19.2 months, respectively. Only one of three polymorphisms examined, rs157077, was significantly associated with overall survival of TACE-treated HCC (P = 0.003), and its mutant allele conferred a higher risk of death than its wild homozygotes (hazard ratio 1.58, 95 % confidence interval 1.17-2.14). Moreover, carriers of this mutant allele had higher tissue GSTO2 expression, reinforcing the prognostic capability of GSTO2 rs157077 for HCC, especially in combination with age and tumor-node-metastasis (TNM) stage. Taken together, we for the first time provided evidence supporting the prognostic role of GSTO2 in the progression of TACE-treated HCC.

Key words

Glutathione S-transferase omega/Hepatocellular carcinoma/Prognosis/Transarterial chemoembolization

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出版年

2015
Tumour biology

Tumour biology

ISSN：1010-4283
被引量1
参考文献量32
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