首页|One-pot method for the synthesis of beta-cyclodextrin and covalent organic framework functionalized chiral stationary phase with mixed-mode retention mechanism

One-pot method for the synthesis of beta-cyclodextrin and covalent organic framework functionalized chiral stationary phase with mixed-mode retention mechanism

扫码查看
原文链接
  • NSTL
  • Elsevier
As a welcomed porous material, covalent organic frameworks (COFs) have many advantages and are widely used in various aspects. Particularly, COFs have aroused great attentions of scientists in chromatographic separation field due to their outstanding advantages, such as high stability, large specific surface area and multiple voids. However, endowing COFs with chirality to construct chiral stationary phase (CSP) function is still facing many challenges. Here, we firstly prepared a beta-cyclodextrin (beta-CD) and covalent organic framework functional silica CSP named as COF@CD@SiO2 by one-pot method to perform high performance liquid chromatography (HPLC) chiral separation. The morphology and structure of the synthesized stationary phase were investigated by a variety of characterization methods including Fourier transform infrared spectrometry (FT-IR), thermogravimetric analysis (TGA), scanning electron microscopy (SEM), N-2 adsorption experiment, powder X-ray diffraction (XRD) and elemental analysis (EA). The prepared stationary phase realized fast separation of six enantiomers in a short time. The separation mechanism was mainly ascribed to the inclusion complexation of beta-cyclodextrin and the mutli-interaction sites from COFs material. In conclusion, the prepared chiral column can be used to achieve fast separation of enantiomers with good stability and reproducibility. These results can open new avenue for using chiral COFs in liquid chromatographic separation. (C) 2021 Elsevier B.V. All rights reserved.

Mixed-modeHigh performance liquid chromatographyChiral stationary phaseCovalent organic frameworksbeta-CyclodextrinEnantiomer separationPERFORMANCE LIQUID-CHROMATOGRAPHYRECOGNITION MECHANISMSNMR-SPECTROSCOPYAMINO-ACIDSSEPARATIONENANTIOSEPARATIONSENANTIOMERSMICROSPHERESSPECTROMETRYADSORPTION

Zheng, Yunchao、Wan, Meijun、Zhou, Jingqiu、Dai, Xuemei、Yang, Honglin、Wang, Lujun、Xia, Zhining

展开 >

Southwest Med Univ

Chongqing Univ

2022

10.1016/j.chroma.2021.462731

Journal of chromatography

Journal of chromatography

ISSN：0021-9673
年,卷(期)：2022.1662
  • 16
  • 55