首页|Primary Paraganglioma of the Spine: A Systematic Review of Clinical Features and Surgical Management in Cauda Equina versus Non–Cauda Equina Lesions

Primary Paraganglioma of the Spine: A Systematic Review of Clinical Features and Surgical Management in Cauda Equina versus Non–Cauda Equina Lesions

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  • NSTL
  • Elsevier
? 2022 Elsevier Inc.Background: Primary spine paragangliomas are rare tumors. Surgical resection plays a role, but aggressive lesions are challenging. We reviewed the literature on primary spine paragangliomas. Methods: PubMed, Scopus, Web of Science, and Cochrane were searched following the PRISMA guidelines to include studies on primary spine paragangliomas. Clinical-radiologic features, treatments, and outcomes were analyzed and compared between cauda equina versus non–cauda equina tumors. Results: We included 143 studies comprising 334 patients. Median age was 46 years (range, 6–85 years). The most frequent symptoms were lower back (64.1%) and radicular (53.9%) pain, and sympathetic in 18 patients (5.4%). Cauda equina paragangliomas (84.1%) had frequently lumbar (49.1%) or lumbosacral (29%) locations. Non–cauda equina tumors were mostly in the thoracic (11.4%), thoracolumbar (5.1%), and cervical (3.6%) spine. Median tumor diameter was 2.5 cm (range, 0.5–13.0 cm). Surgical resection (98.5%) was preferred over biopsy (1.5%). Decompressive laminectomy (53%) and spine fusion (6.9%) were also performed. Adjuvant radiotherapy was delivered in 39 patients (11.7%) with aggressive tumors. Posttreatment symptomatic improvement was described in 86.2% cases. Median follow-up was 19.5 months (range, 0.1–468.0 months), and 23 patients (3.9%) had tumor recurrences. No significant differences were found between cauda equina versus non–cauda equina tumors. Conclusions: Surgical resection is effective and safe in treating primary spine paragangliomas; however, adjuvant treatments may be needed for aggressive lesions.

Cauda equinaParagangliomaSpineSurgical oncology

Vira S.、Palmisciano P.、Sagoo N.S.、Haider A.S.、Ogasawara C.、Ogasawara M.、Bin Alamer O.、Heidari K.S.、Raj K.M.、Scalia G.、Umana G.E.、Krishnaney A.A.、Aoun S.G.、Passias P.G.

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Department of Orthopaedic Surgery University of Texas Southwestern Medical Center

Department of Neurosurgery Trauma Center Gamma Knife Center Cannizzaro Hospital

Texas A&M University College of Medicine

John A. Burns School of Medicine University of Hawai'i

University of California

King Abdullah International Medical Research Center

Department of Radiology University of Texas Southwestern Medical Center

Department of Neurosurgery Highly Specialized Hospital of National Importance “Garibaldi” Catania

Department of Neurosurgery Cleveland Clinic

Department of Neurological Surgery University of Texas Southwestern Medical Center

Department of Orthopaedic Surgery NYU Langone Orthopedic Hospital

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2022

10.1016/j.wneu.2022.01.110

World neurosurgery

World neurosurgery

SCI
ISSN：1878-8750
年,卷(期)：2022.161
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