Abstract
The coordination properties of Pt(II) with 5-amino-1,3,4-thiadiazole-2- thiol [CAS 2349-67-9] (L 1) and its novel violurate adduct (L 2), both in solution and in solid state, are studied by means of conventional IR-spectroscopy, single crystal X-ray diffraction and thermal methods. The complex compounds of L 1 and L 2, with general formulas [Pt(C2H2N3S2) 2] and [Pt(C6H4N6S2O 3)(Cl)]Cl respectively, are obtained. Quantum chemical calculations of the ligands are performed with a view to obtain electronic structure and optical properties of the ligands L 1 and L 2, respectively. The cell viability of the ligands and metal complexes on a panel of human tumor cell lines is evaluated.
NSTL
Thieme Medical Publishers