首页|Kiiacylphnols A?H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim

Kiiacylphnols A?H, eight undescribed polycyclic polyprenylated acylphloroglucinols with anticancer activities from Hypericum przewalskii Maxim

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  • NSTL
  • Elsevier
? Elsevier LtdKiiacylphnols A?H, eight previously undescribed polycyclic polyprenylated acylphloroglucinols (PPAPs), along with two known congeners (hyperforcinol F and oxepahyperforin), were obtained from Hypericum przewalskii Maxim. The structures of these metabolites were confirmed by spectroscopic analyses, quantum-chemical 1H and 13C NMR calculations with DP4+ analyses, electronic circular dichroism (ECD) comparisons and calculations. Kiiacylphnols A and B were the first [3.3.1]-type PPAPs with an unusual octahydrooxireno[2,3-i]chromene scaffold bearing a rare 6/6/6/3 ring system. More significantly, kiiacylphnol A and oxepahyperforin displayed cytotoxicity against acute myeloid leukemia and diffuse large B-cell lymphoma cell lines by inducing cell apoptosis.

Cytotoxic activityHypericaceaeHypericum przewalskii Maxim.Polycyclic polyprenylated acylphloroglucinols

Hu P.、Duan Y.、Guo Y.、Bu P.、Shi Z.、Cao Y.、Zhang Y.、Hu H.、Tong Q.、Qi C.

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Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation School of Pharmacy Tongji Medical College Huazhong University of Science and Technology

2022

10.1016/j.phytochem.2022.113166

Phytochemistry

Phytochemistry

CCR
ISSN：0031-9422
年,卷(期)：2022.199
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