Steroidal Saponins from the Rhizomes of Anemarrhena asphodeloides
Yang, Bing-You 1Zhang, Jing 1Liu, Yan 1Kuang, Hai-Xue1
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作者信息
1. Heilongjiang Univ Chinese Med, Key Lab Chinese Mat Med, Minist Educ, Harbin 150040, Peoples R China
折叠
Abstract
Four new steroid saponins 1-4 were isolated from the rhizomes of Anemarrhena asphodeloides (Asparagaceae), as well as four known saponins: anemarsaponin B (5) timosaponin D (6), timosaponin E1 (7) anemarsaponin B II (8). Their structures were established through UV and NMR as well as MS data. All the compounds were evaluated for cytotoxicity against HepG2 and SGC7901 human cancer lines. Compounds 3 and 7 displayed medium antiproliferative activities on HepG2 and SGC7901 cells, with IC50 values of 43.90 and 57.90 mu M, respectively.
NSTL
Mdpi