Six new secoiridoid glycosides from the stem barks of Syringa Reticulata (Bl.) Hara
Liu, Yan 1Zhu, Hui-Chen 1Guo, Shuang 1Liu, Pei 1Zou, Hai-Dan 1Naseem, Anam 1Pan, Juan 1Guan, Wei 1Kuang, Hai-Xue 1Yang, Bing-You1
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作者信息
1. Heilongjiang Univ Chinese Med
折叠
Abstract
Six new secoiridoids, syrretosides E-J (1-6) and four known secoiridoids (7-10), were isolated from the stem barks of Syringa reticulata. Their structures were established by the 1D and 2D NMR spectra, HR-ESI-MS, and comparison with the literature. The cytotoxicity of the isolated monomeric compounds against RAW264.7 cells was investigated by the CCK8 assay, and the results showed that the individual compounds were not cytotoxic to RAW264.7. The anti-inflammatory activity of these compounds was evaluated using the LPS-induced RAW264.7 inflammatory cell model and the results showed that compounds 3-7 and 9 showed varying degrees of anti-inflammatory activity.
NSTL
Elsevier