Tetrahedron letters2022，Vol.886.DOI:10.1016/j.tetlet.2021.153511

Direct C3-H carbamoylation of quinoxalin-2(1H)-ones with isocyanides enabled by selectfluor II under mild conditions

Li, Jing Hu, Jie Xiao, Yao Yin, Kun Dan, Wenyan Fan, Suhua Jin, Feng Wu, Hai Zhang, Ronghua Li, Jian
Tetrahedron letters2022，Vol.886.DOI:10.1016/j.tetlet.2021.153511
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  • NSTL
  • Elsevier

Direct C3-H carbamoylation of quinoxalin-2(1H)-ones with isocyanides enabled by selectfluor II under mild conditions

Li, Jing 1Hu, Jie 2Xiao, Yao 2Yin, Kun 1Dan, Wenyan 3Fan, Suhua 1Jin, Feng 1Wu, Hai 1Zhang, Ronghua 3Li, Jian2
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作者信息

  • 1. Fuyang Normal Univ
  • 2. Shanghai Univ
  • 3. Tongji Univ
  • 折叠

Abstract

A F reagent-mediated direct C-H carbamoylation of quinoxalin-2(1H)-ones has been developed. Under room temperature, a variety of isocyanides are employed to couple well with quinoxalin-2(1H)-ones affording 42 examples including 30 new compounds. This metal-free mild strategy tolerates a wide range of functional groups and shows environmental friendliness and practicality. (C) 2021 Elsevier Ltd. All rights reserved.

Key words

Quinoxalin-2(1H)-one/Isocyanide/C-H carbamoylation/Selectfluor II/Room temperature/C-H ARYLATION/METAL/DERIVATIVES/DESIGN/SALTS/ISONITRILES/INHIBITORS/DISCOVERY/ACCESS/AMINES

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出版年

2022
Tetrahedron letters

Tetrahedron letters

CCR
ISSN：0040-4039
被引量3
参考文献量54
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