首页|Bioassay-guided isolation of antifungal cyclopeptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020
Bioassay-guided isolation of antifungal cyclopeptides from the deep-sea-derived fungus Simplicillium obclavatum EIODSF 020
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NSTL
Elsevier
? 2022 Phytochemical Society of EuropeTwo new cyclopeptides simplicilliumtides N and O (1 and 2) along with three known analogues verlamelins A, B and simplicilliumtide J (3-5) were isolated from the deep-sea-derived fungal strain Simplicillium obclavatum EIODSF 020 by bioassay-guided isolation method. Their structures of 1 and 2 were elucidated by spectroscopic analysis, and their amino acid configurations were determined by Marfey's method. All isolated compounds showed significant antifungal activity against two phytopathogenic fungi Alternaria solani and Colletotricum asianum with MIC values of 0.195–6.250 μg/disc. This study suggests the fungal strain S. obclavatum EIODSF 020 is a new source for developing natural fungicides.
CAS Key Laboratory of Tropical Marine Bio-resources and Ecology Guangdong Key Laboratory of Marine Materia Medica South China Sea Institute of Oceanology Chinese Academy of Sciences
NSTL
Elsevier
