首页|Insights into the molecular biology of adrenocortical tumors.
Insights into the molecular biology of adrenocortical tumors.
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Adrenocortical tumors are rare tumors which can cause morbidity secondary to hyper secretion (i. e. Cushing's syndrome in adrenocortical adenoma or carcinoma, mineralocorticoid excess in Conn's adenoma) or to their oncogenic growth and metastases.In the recent years progress has been made in our understanding of the pathophysiology of these endocrine tumors (Latronico and Chrousos, 1997; Bornstein et al., 1999; Reincke et al., 2000; Bertherat et al., 2002). Some molecular mechanisms of hormone hypersecretion or growth of adrenocortical tumors have been unraveled this last decade and offer new support to our understanding of adrenocortical tumor development. In particular, studies of familial forms of adrenocortical tumors have given us new insight in the genetics of these tumors. Some of these advances have already lead to new therapeutical or diagnostic approaches.
Molecular Biology分子生物学
Groussin L、Bertherat J、Gicquel C、le-Bouc Y、Bertagna X
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Clinique des Maladies Endocriniennes et Metaboliques, Endocrinology Department, Institut Cochin Faculte de Medecine Rene, Paris, France. German Society of Endocrinology [and] German Diabetes Association
2007
Experimental and clinical endocrinology and diabetes
NSTL
