首页|Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration
Pharmacokinetics of meloxicam in laying hens after single intravenous, oral, and intramuscular administration
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NSTL
Wiley
Abstract The objective of this study was to determine the pharmacokinetics of meloxicam after a single intravenous (IV), intramuscular (IM), and oral (PO) dose at 1?mg/kg body weight in Jing Hong laying hens. Blood samples were collected at predetermined time points. Plasma meloxicam concentrations were determined using a validated high‐performance liquid chromatography (HPLC) assay method and then subjected to a non‐compartmental analysis. After IV administration, meloxicam had a mean (±SD) volume of distribution at steady‐state (Vdss) of 206.50?±?25.23?ml/kg, a terminal half‐life (t1/2λ) of 5.45?±?0.53?h, and a total body clearance (Cl) of 26.48?±?4.13?ml/h/kg. After PO and IM administration, meloxicam was absorbed relatively rapidly: the peak concentrations (Cmaxs) of 3.04?±?0.56 and 8.94?±?2.31?μg/ml were observed at 3.08 and 0.80?h, respectively. After PO and IM administration, the absolute bioavailability (F) was determined as 70.13% and 125.50%, respectively. Assuming that hens shared the same analgesic threshold of meloxicam (0.5?μg/ml) with humans, the plasma concentrations after three different routes (PO, IM, and IV) of administration were above this value for 16.7, 19.2, and 14.9?h, respectively.
extravascular bioavailabilityHPLCJing Hong laying hensmeloxicampharmacokinetics
Hao‐Tian Shao、Fang Yang、Jun‐Cheng Chen、Mei Zhang、Zhe‐Wen Song、Fan Yang
NSTL
Wiley
